Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2002-12-17
pubmed:abstractText
A key molecule necessary for activation of T lymphocytes through their antigen-specific T cell receptor (TCR) is the transmembrane adaptor protein LAT (linker for activation of T cells). Upon TCR engagement, LAT becomes rapidly tyrosine phosphorylated and then serves as a scaffold organizing a multicomponent complex that is indispensable for induction of further downstream steps of the signaling cascade. Here we describe the identification and preliminary characterization of a novel transmembrane adaptor protein that is structurally and evolutionarily related to LAT and is expressed in B lymphocytes, natural killer (NK) cells, monocytes, and mast cells but not in resting T lymphocytes. This novel transmembrane adaptor protein, termed NTAL (non-T cell activation linker) is the product of a previously identified WBSCR5 gene of so far unknown function. NTAL becomes rapidly tyrosine-phosphorylated upon cross-linking of the B cell receptor (BCR) or of high-affinity Fcgamma- and Fc epsilon -receptors of myeloid cells and then associates with the cytoplasmic signaling molecules Grb2, Sos1, Gab1, and c-Cbl. NTAL expressed in the LAT-deficient T cell line J.CaM2.5 becomes tyrosine phosphorylated and rescues activation of Erk1/2 and minimal transient elevation of cytoplasmic calcium level upon TCR/CD3 cross-linking. Thus, NTAL appears to be a structural and possibly also functional homologue of LAT in non-T cells.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-10204488, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-10375551, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-10438904, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-10586892, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-10663578, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-10781401, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-10781611, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-10790433, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-10801129, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-10811803, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-10843385, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-11003705, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-11278704, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-11293120, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-11329010, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-11390434, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-11420035, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-11429318, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-11449366, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-11491537, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-11713268, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-11909947, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-11943184, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-11988768, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-1382093, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-1955119, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-3017146, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-7226224, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-7585947, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-8347295, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-8517920, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-8812460, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-9489702, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-9675140, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-9697839, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-9705962, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-9729044, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-9804835, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-9826536, http://linkedlifedata.com/resource/pubmed/commentcorrection/12486104-9846483
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/LAT protein, human, http://linkedlifedata.com/resource/pubmed/chemical/LAT2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Lat protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fc, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG, http://linkedlifedata.com/resource/pubmed/chemical/Wbscr5 protein, mouse
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
196
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1617-26
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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