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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2002-12-17
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pubmed:abstractText |
PPAR-gamma/RXR heterodimers play a key regulatory role in murine placental development. We report here that PPAR-gamma and RXR-alpha are highly expressed in cultured primary extravillous cytotrophoblasts (EVCT) isolated from human first-trimester placenta. Using this cell culture model, we showed that PPAR-gamma agonists inhibit EVCT invasion, whereas PPAR-gamma or pan-RXR antagonists promoted EVCT invasion by themselves and abolished PPAR-gamma agonist-mediated effect. Together these data underscore an important function of PPAR/RXR heterodimers in the modulation of trophoblast invasion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0077-8923
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
973
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
26-30
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:12485829-Animals,
pubmed-meshheading:12485829-Cells, Cultured,
pubmed-meshheading:12485829-Dimerization,
pubmed-meshheading:12485829-Female,
pubmed-meshheading:12485829-Humans,
pubmed-meshheading:12485829-Mice,
pubmed-meshheading:12485829-Placenta,
pubmed-meshheading:12485829-Pregnancy,
pubmed-meshheading:12485829-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:12485829-Receptors, Retinoic Acid,
pubmed-meshheading:12485829-Retinoid X Receptors,
pubmed-meshheading:12485829-Transcription Factors,
pubmed-meshheading:12485829-Trophoblasts
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pubmed:year |
2002
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pubmed:articleTitle |
The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion.
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pubmed:affiliation |
INSERM U427, Faculté de Pharmacie, 75006 Paris, France. t.f@pharmacie.univ-paris5.fr
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pubmed:publicationType |
Journal Article
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