Source:http://linkedlifedata.com/resource/pubmed/id/12483412
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2002-12-16
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| pubmed:abstractText |
Amino acid transport system A is expressed strongly in neoplastic cells. [ N-methyl-(11)C]alpha-Methylaminoisobutyric acid ((11)C-MeAIB) is a recently developed tracer for PET studies on system A amino acid transport. (11)C-MeAIB is a metabolically stable amino acid analogue which is transported from plasma into the tissue by system A. This study evaluated the kinetics of (11)C-MeAIB uptake from plasma into tumour tissue and normal tissues in 13 patients with untreated head and neck cancer. (11)C-MeAIB uptake in tumour was compared with histological grade and proliferative activity. Tracer uptake was quantitated by calculating the standardised uptake values (SUVs) and the kinetic influx constants ( K(i)) using graphical analysis. All tumours accumulated (11)C-MeAIB and were visualised clearly. In the graphical analysis, linear plots were achieved; the mean K(i) value of tumour was 0.056+/-0.026 min(-1), and the mean SUV was 6.1+/-2.7. A close correlation between graphically obtained K(i) and semi-quantitative SUV in tumours was found ( r=0.887, P=0.00005). We could not demonstrate a correlation between the uptake of (11)C-MeAIB and the grade of malignancy or the proliferative index, as assessed using Ki-67 immunohistochemical assay. Head and neck cancer can be effectively imaged with (11)C-MeAIB PET. (11)C-MeAIB showed active and rapid transport into tumour tissue and salivary glands. Further studies on the applicability of (11)C-MeAIB PET for radiation treatment planning in the head and neck region and the regulation of system A amino acid transport under different metabolic states are warranted.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
|
| pubmed:issn |
1619-7070
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
72-7
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12483412-Adult,
pubmed-meshheading:12483412-Aged,
pubmed-meshheading:12483412-Carbon Radioisotopes,
pubmed-meshheading:12483412-Carcinoma, Adenoid Cystic,
pubmed-meshheading:12483412-Female,
pubmed-meshheading:12483412-Head and Neck Neoplasms,
pubmed-meshheading:12483412-Humans,
pubmed-meshheading:12483412-Male,
pubmed-meshheading:12483412-Metabolic Clearance Rate,
pubmed-meshheading:12483412-Middle Aged,
pubmed-meshheading:12483412-Neoplasm Staging,
pubmed-meshheading:12483412-Neoplasms, Squamous Cell,
pubmed-meshheading:12483412-Organ Specificity,
pubmed-meshheading:12483412-Radiopharmaceuticals,
pubmed-meshheading:12483412-Reproducibility of Results,
pubmed-meshheading:12483412-Sensitivity and Specificity,
pubmed-meshheading:12483412-Tissue Distribution,
pubmed-meshheading:12483412-Tomography, Emission-Computed,
pubmed-meshheading:12483412-beta-Alanine
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Uptake of [N-methyl-11C]alpha-methylaminoisobutyric acid in untreated head and neck cancer studied by PET.
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| pubmed:affiliation |
Turku PET Centre, Turku University Central Hospital, Turku, Finland. eija.sutinen@pet.tyks.fi
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't,
Validation Studies
|