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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-12-16
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pubmed:abstractText |
We previously reported that a total methanolic extract of the underground part of Angelica gigas Nakai (Umbelliferae) (here-in-after abbreviated AG) significantly inhibited acetylcholinesterase (AChE) activity. We characterized 12 coumarin derivatives including both decursin and decursinol from extracts of AG. In this study, we evaluated the anti-amnestic activity of decursin, a major coumarin constituent isolated from AG, in vivo using ICR mice with amnesia induced by scopolamine (1 mg/kg body weight, s.c.). Decursin, when administered to mice at 1 and 5 mg/kg body weight i.p., significantly ameliorated scopolamine-induced amnesia as measured in both the passive avoidance test and the Morris water maze test. Moreover, decursin significantly inhibited AChE activity by 34% in the hippocampus of treated mice. These results indicate that decursin may exert anti-amnestic activity in vivo through inhibition of AChE activity in the hippocampus.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1074-7427
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12482674-Acetylcholinesterase,
pubmed-meshheading:12482674-Amnesia,
pubmed-meshheading:12482674-Angelica,
pubmed-meshheading:12482674-Animals,
pubmed-meshheading:12482674-Avoidance Learning,
pubmed-meshheading:12482674-Benzopyrans,
pubmed-meshheading:12482674-Brain,
pubmed-meshheading:12482674-Butyric Acids,
pubmed-meshheading:12482674-Cholinesterase Inhibitors,
pubmed-meshheading:12482674-Disease Models, Animal,
pubmed-meshheading:12482674-Male,
pubmed-meshheading:12482674-Maze Learning,
pubmed-meshheading:12482674-Memory,
pubmed-meshheading:12482674-Mice,
pubmed-meshheading:12482674-Mice, Inbred ICR,
pubmed-meshheading:12482674-Muscarinic Antagonists,
pubmed-meshheading:12482674-Plant Extracts,
pubmed-meshheading:12482674-Scopolamine Hydrobromide
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pubmed:year |
2003
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pubmed:articleTitle |
Decursin from Angelica gigas mitigates amnesia induced by scopolamine in mice.
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pubmed:affiliation |
College of Pharmacy, Seoul National University, Kwanak-Gu San 56-1, Shillim-Dong, Seoul 151-742, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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