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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-12-16
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425609,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425610,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425611,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425612,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425613,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425614,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425615,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425616,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425617,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425618,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425619,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425620,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425621,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425622,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425623,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425624,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425625,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425626,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425627,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425628,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425629,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425630,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425631,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425632,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425633,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425634,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425635,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425636,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425637,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425638,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF425639
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pubmed:abstractText |
The genetic diversity and phylogenetic relationships of a collection of strains of dengue virus type 1 (DV-1), isolated from different parts of the world, were investigated. Phylogenetic trees derived from the complete sequence of the E gene of 44 strains suggested the existence of five genetic types defined by a maximum nucleotide divergence within each group of 6%. The 22 strains from America were classified into a single genetic type that included strains associated either with classical dengue or hemorrhagic dengue episodes. Using a maximum likelihood procedure based on a single rate with dated tips model and substitution rates calculated at the third codon position, evolution of the five DV-1 genotypes was shown to conform to a molecular clock. The average rate of evolution was estimated to be approximately 16.2 x 10(-4) substitutions/third codon position site/year. Using this estimate, divergence among the DV-1 genotypes was calculated to have occurred approximately 100 years ago. Very low average value of the ratio of nonsynonymous-to-synonymous nucleotide substitutions, relative to the respective sites (0.046), indicated that the evolution of the E gene of the DV-1 is subject mostly to purifying selection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0042-6822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
303
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
110-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12482662-Dengue,
pubmed-meshheading:12482662-Dengue Virus,
pubmed-meshheading:12482662-Evolution, Molecular,
pubmed-meshheading:12482662-Genetic Variation,
pubmed-meshheading:12482662-Genotype,
pubmed-meshheading:12482662-Humans,
pubmed-meshheading:12482662-Molecular Epidemiology,
pubmed-meshheading:12482662-Molecular Sequence Data,
pubmed-meshheading:12482662-Phylogeny,
pubmed-meshheading:12482662-RNA, Viral,
pubmed-meshheading:12482662-Sequence Analysis,
pubmed-meshheading:12482662-Time Factors,
pubmed-meshheading:12482662-Viral Envelope Proteins,
pubmed-meshheading:12482662-World Health
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pubmed:year |
2002
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pubmed:articleTitle |
Diversity and evolution of the envelope gene of dengue virus type 1.
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pubmed:affiliation |
Instituto Venezolano de Investigaciones Cienti;ficas, Caracas, Venezuela.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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