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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-12-16
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pubmed:abstractText |
We synthesized and evaluated N-(5-fluoro-2-phenoxyphenyl)-N-(2-[(18)F]fluoromethyl-5-methoxybenzyl)acetamide ([(18)F]-FMDAA1106) and N-(5-fluoro-2-phenoxyphenyl)-N-(2-[(18)F]fluoroethyl-5-methoxybenzyl)acetamide ([(18)F]FEDAA1106) as two potent radioligands for peripheral benzodiazepine receptors (PBR). [(18)F]FMDAA1106 and [(18)F]FEDAA1106 were respectively synthesized by fluoroalkylation of the desmethyl precursor DAA1123 with [(18)F]FCH(2)I and [(18)F]FCH(2)CH(2)Br. Ex vivo autoradiograms of [(18)F]FMDAA1106 and [(18)F]FEDAA1106 binding sites in the rat brains revealed that a high radioactivity was present in the olfactory bulb, the highest PBR density region in the brain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
201-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12482423-Acetamides,
pubmed-meshheading:12482423-Animals,
pubmed-meshheading:12482423-Autoradiography,
pubmed-meshheading:12482423-Binding, Competitive,
pubmed-meshheading:12482423-Brain,
pubmed-meshheading:12482423-Brain Chemistry,
pubmed-meshheading:12482423-Central Nervous System,
pubmed-meshheading:12482423-Electrons,
pubmed-meshheading:12482423-Flumazenil,
pubmed-meshheading:12482423-Fluorine Radioisotopes,
pubmed-meshheading:12482423-GABA Modulators,
pubmed-meshheading:12482423-Mice,
pubmed-meshheading:12482423-Peripheral Nerves,
pubmed-meshheading:12482423-Radiopharmaceuticals,
pubmed-meshheading:12482423-Receptors, GABA-A,
pubmed-meshheading:12482423-Tomography, Emission-Computed
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pubmed:year |
2003
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pubmed:articleTitle |
[18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR).
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pubmed:affiliation |
Department of Medical Imaging, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. zhang@nirs.go.jp
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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