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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-12-16
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pubmed:abstractText |
Four pyrrolidine derivatives were prepared by the formation of a 5-membered ring based on capsazepine. Among them, the two carbon extended derivatives, 4a (IC(50)=55 microM) and 4b (IC(50)=3 microM), both showed different levels of antagonist activity against the vanilloid receptor in a (45)Ca(2+)-influx assay.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:ChoiJi yeonJ,
pubmed-author:ChoiJin KyuJK,
pubmed-author:ChoiSea hoonS,
pubmed-author:JeongYeon SuYS,
pubmed-author:JewSang supS,
pubmed-author:KIRSHBAUMB ABA,
pubmed-author:LeeJeewooJ,
pubmed-author:LeeJihyeJ,
pubmed-author:OhUhtaekU,
pubmed-author:ParkHyeung geunH,
pubmed-author:ParkMi kyungM,
pubmed-author:ParkYoung HoYH,
pubmed-author:SuhYoung gerY
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
197-200
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12482422-Animals,
pubmed-meshheading:12482422-Animals, Newborn,
pubmed-meshheading:12482422-Calcium,
pubmed-meshheading:12482422-Capsaicin,
pubmed-meshheading:12482422-Crystallography, X-Ray,
pubmed-meshheading:12482422-Indicators and Reagents,
pubmed-meshheading:12482422-Models, Molecular,
pubmed-meshheading:12482422-Molecular Conformation,
pubmed-meshheading:12482422-Neurons, Afferent,
pubmed-meshheading:12482422-Pyrrolidines,
pubmed-meshheading:12482422-Rats,
pubmed-meshheading:12482422-Receptors, Drug,
pubmed-meshheading:12482422-Thiourea
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pubmed:year |
2003
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pubmed:articleTitle |
Synthesis of 2-substituted-pyrrolidinethiourea derivatives and their antagonist effect on vanilloid receptor.
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pubmed:affiliation |
Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 151-742, South Korea. hgpk@plaza.snu.ac.kr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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