Linked Life Data

12482391

Source:http://linkedlifedata.com/resource/pubmed/id/12482391

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-12-16
pubmed:abstractText
In a previous study, we showed that nonobese diabetic (NOD) mice, a strain that present an inherited predisposition to develop both spontaneous and induced autoimmune lesions, are susceptible to the induction of experimental autoimmune prostatitis (EAP), developing a severe inflammatory reaction in the prostate, accompanied by humoral and T-cell-mediated responses. In this study we asked whether the protein steroid binding protein (PSBP) or prostatein (a major autoantigen in the rat model of EAP) is a potential autoantigen in the NOD mouse model and examined the ability of purified PSBP to induce EAP in this strain. Our results indicate clearly that NOD male mice react immunologically to PSBP by developing lymphocytic inflammatory lesions in prostatic tissue and producing both a cellular- and humoral-specific autoimmune response. But our results suggest also the existence of other prostatic autoantigens present only in total prostate extract. Such additional antigens could enhance the autoimmune response and result in more severe forms of inflammation. We also analyzed the respective contributions of MHC antigens and CD4/CD8 T-cell subsets in NOD mice lacking expression of beta 2-microglobulin (NOD.beta2m degrees/degrees) or MHC class II beta chain (NOD.Abeta degrees/degrees) and demonstrate an essential role for CD4(+) T cells in the development of EAP in the NOD model. In conclusion, we demonstrate that PSBP is an autoantigen recognized by the NOD immune system, capable of generating humoral and cellular autoimmune responses and of inducing EAP. Moreover, using selected knock-out NOD mice we demonstrate an essential role for CD4(+) T cells in the development of EAP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1521-6616
pubmed:author
pubmed:issnType
Print
pubmed:volume
105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
176-84
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:12482391-Androgen-Binding Protein, pubmed-meshheading:12482391-Animals, pubmed-meshheading:12482391-Autoantibodies, pubmed-meshheading:12482391-Autoantigens, pubmed-meshheading:12482391-Autoimmune Diseases, pubmed-meshheading:12482391-CD4-Positive T-Lymphocytes, pubmed-meshheading:12482391-Histocompatibility Antigens Class II, pubmed-meshheading:12482391-Immunization, pubmed-meshheading:12482391-Kinetics, pubmed-meshheading:12482391-Lymphocyte Activation, pubmed-meshheading:12482391-Male, pubmed-meshheading:12482391-Mice, pubmed-meshheading:12482391-Mice, Inbred NOD, pubmed-meshheading:12482391-Mice, Knockout, pubmed-meshheading:12482391-Prostatein, pubmed-meshheading:12482391-Prostatitis, pubmed-meshheading:12482391-Secretoglobins, pubmed-meshheading:12482391-Uteroglobin, pubmed-meshheading:12482391-beta 2-Microglobulin
pubmed:year
2002
pubmed:articleTitle
Prostatein or steroid binding protein (PSBP) induces experimental autoimmune prostatitis (EAP) in NOD mice.
pubmed:affiliation
Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina. vrivero@bioclin.fcq.unc.edu.ar
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't