Source:http://linkedlifedata.com/resource/pubmed/id/12482144
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2002-12-16
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| pubmed:abstractText |
Evidence of transplant recipient cellular sensitization towards donor antigens has rarely been directly measured. Rather, sensitization has been generally inferred by the presence of detectable allo-reactive or donor-reactive antibodies. In this study a newly developed delayed-type hypersensitivity assay was used to directly determine the incidence of post-transplant donor-reactive T-cell sensitization in a large cohort of kidney and simultaneous kidney-pancreas recipients. These results were compared with the presence of detectable circulating alloantibodies and with patient clinical outcome. We found an unexpectedly high incidence (52%) of donor-reactive delayed-type hypersensitivity reactivity in our study patients. Donor-reactive delayed-type hypersensitivity reactivity occurred at a much higher frequency than detectable alloantibodies (20%). Further, we found no correlation between the presence of alloantibodies and donor-reactive delayed-type hypersensitivity reactivity. We also found no correlation between the development of donor-reactive delayed-type hypersensitivity reactivity and the degree of donor and recipient HLA matching. Finally, the presence of detectable donor-reactive delayed-type hypersensitivity reactivity did not correlate with a worse clinical outcome at the time of these analyses. We conclude that in transplant recipients, the presence of circulating alloantibodies is a poor indicator of previous T-cell sensitization to donor antigens. We also conclude that our current immunosuppression strategies are relatively ineffective at blocking T-cell allosensitization, but are very effective at blocking the biological consequences of that allosensitization.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1600-6135
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
2
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
926-33
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:12482144-Acute Disease,
pubmed-meshheading:12482144-Continental Population Groups,
pubmed-meshheading:12482144-Female,
pubmed-meshheading:12482144-Graft Rejection,
pubmed-meshheading:12482144-Histocompatibility Testing,
pubmed-meshheading:12482144-Humans,
pubmed-meshheading:12482144-Hypersensitivity, Delayed,
pubmed-meshheading:12482144-Immunosuppressive Agents,
pubmed-meshheading:12482144-Incidence,
pubmed-meshheading:12482144-Isoantibodies,
pubmed-meshheading:12482144-Kidney Transplantation,
pubmed-meshheading:12482144-Male,
pubmed-meshheading:12482144-Pancreas Transplantation,
pubmed-meshheading:12482144-Postoperative Complications,
pubmed-meshheading:12482144-Retrospective Studies,
pubmed-meshheading:12482144-T-Lymphocytes,
pubmed-meshheading:12482144-Tissue Donors,
pubmed-meshheading:12482144-United States
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
High incidence of donor-reactive delayed-type hypersensitivity reactivity in transplant patients.
|
| pubmed:affiliation |
The Ohio State University College of Medicine and Public Health, Department of Surgery, Columbus, Ohio 43210, USA. pelletier-1@medctr.osu.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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