|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0012634,
umls-concept:C0016627,
umls-concept:C0024432,
umls-concept:C0042776,
umls-concept:C0079189,
umls-concept:C0086418,
umls-concept:C0205263,
umls-concept:C0439793,
umls-concept:C0441712,
umls-concept:C2076600,
umls-concept:C2700116
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|
pubmed:issue |
9348
|
|
pubmed:dateCreated |
2002-12-13
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|
pubmed:abstractText |
In 1997, the first documented instance of human respiratory disease and death associated with a purely avian H5N1 influenza virus resulted in an overall case-fatality rate of 33%. The biological basis for the severity of human H5N1 disease has remained unclear. We tested the hypothesis that virus-induced cytokine dysregulation has a role.
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|
pubmed:commentsCorrections |
|
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0140-6736
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:day |
7
|
|
pubmed:volume |
360
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1831-7
|
|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:12480361-Cells, Cultured,
pubmed-meshheading:12480361-Cytokines,
pubmed-meshheading:12480361-Gene Expression Regulation,
pubmed-meshheading:12480361-Humans,
pubmed-meshheading:12480361-Influenza, Human,
pubmed-meshheading:12480361-Influenzavirus A,
pubmed-meshheading:12480361-Macrophages,
pubmed-meshheading:12480361-RNA, Messenger,
pubmed-meshheading:12480361-Severity of Illness Index,
pubmed-meshheading:12480361-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?
|
|
pubmed:affiliation |
Department of Microbiology, University of Hong Kong, Queen Mary Hospital, SAR, Hong Kong, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
