Source:http://linkedlifedata.com/resource/pubmed/id/12480250
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2002-12-13
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pubmed:abstractText |
It is generally accepted that dendritic cells can be generated from either myeloid or lymphoid derived progenitors. Ample information has been collected on the development and nature of myeloid DC type 1 (DC1). In contrast, our current understanding on the origin and function of the lymphoid derived DC type 2 (DC2) is still limited but is increasing rapidly. Here we will summarize recent findings on the developmental origin of the precursor of DC2 (pre-DC2). The presence of pre-DC2 has been revealed in bone marrow, fetal liver, and cord blood, where they develop from hematopoietic stem cells (HSC) most likely via an intermediate pro-DC2 stage. Both in human and mouse, development of pre-DC2 depends on the cytokine FLT3-ligand (FLT3-L). In addition, transcription factors such as Spi-B and members of the basic helix-loop helix (bHLH) family have been shown to be involved in the proper differentiation of HSC into pre-DC2. The human thymus contains a population of cells that closely resembles the peripheral pre-DC2, including interferon (INF)-a production after viral stimulation. Some phenotypic differences have been observed however. Furthermore, we have shown that the thymic microenvironment is able to support development of pre-DC2 from HSC in vivo. A thymus independent pathway of pre-DC2 development exists as well, although at present it is not clear where these extrathymic pre-DC2 are generated. In regard of the absence of a phenotypic defined pro-DC2 population in the thymus, we speculate that development of thymic pre-DC2 may differ from peripheral pre-DC2. The challenge of the near future will be to determine the role of pre-DC2 during thymic T cell development.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0198-8859
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1072-80
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pubmed:dateRevised |
2005-11-16
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pubmed:meshHeading |
pubmed-meshheading:12480250-Animals,
pubmed-meshheading:12480250-Antigens, CD2,
pubmed-meshheading:12480250-Antigens, CD34,
pubmed-meshheading:12480250-Cell Differentiation,
pubmed-meshheading:12480250-Cell Lineage,
pubmed-meshheading:12480250-Dendritic Cells,
pubmed-meshheading:12480250-Fetal Blood,
pubmed-meshheading:12480250-Gene Expression Regulation, Developmental,
pubmed-meshheading:12480250-Hematopoietic Stem Cells,
pubmed-meshheading:12480250-Humans,
pubmed-meshheading:12480250-Thymus Gland
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pubmed:year |
2002
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pubmed:articleTitle |
Developmental origin of pre-DC2.
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pubmed:affiliation |
Division of Immunology, Plesmanlaan 121, Amsterdam, The Netherlands. b.blom@nki.nl
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pubmed:publicationType |
Journal Article,
Review
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