12479130

Source:http://linkedlifedata.com/resource/pubmed/id/12479130

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0033634, umls-concept:C0037868, umls-concept:C0600485, umls-concept:C1510470
pubmed:issue	5
pubmed:dateCreated	2002-12-13
pubmed:abstractText	Protein kinase C (PKC) is localized in the equatorial segment and the principal piece of the tail of spermatozoa. Activator of PKC results in increasing flagellar motility of sperm that is blocked by PKC inhibitors such as staurosporine. A good correlation (r = 0.9, P < 0.001) is found between the content of PKC in sperm and sperm motility. Zona pellucida (ZP) stimulates the spermatozoa binding the acrosome reaction resulting in the release of hydrolytic enzymes and in the exposure of new membrane domains. ZP binding to receptors in the plasma membrane can regulate adenyl cyclase (AC) leading to elevation of cAMP and protein kinase A (PKA) activation. The PKA activates a voltage-dependent Ca2+ channel in the outer acrosomal membrane which releases Ca2+ from the interior of the acrosome to the cytosol. Activation of the PLC resulted from the rise in Ca2+ hydrolyze phosphatidyl inositol bisphosphate. The product activate PCK to open a voltage-dependent Ca2+ channel (L) in the plasma membrane, leading to the second (II) Ca2+ higher increase which result in membrane fusion and acrosome reaction. It is proposed that PKC would be involved in the regulation of motility and acrosome reaction of sperm.
pubmed:language	chi
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101093592
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C
pubmed:status	MEDLINE
pubmed:issn	1009-3591
pubmed:author	pubmed-author:LiuJi-HongJH, pubmed-author:YangLiL
pubmed:issnType	Print
pubmed:volume	8
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	367-70
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:12479130-Acrosome Reaction, pubmed-meshheading:12479130-Humans, pubmed-meshheading:12479130-Male, pubmed-meshheading:12479130-Protein Kinase C, pubmed-meshheading:12479130-Sperm Motility, pubmed-meshheading:12479130-Spermatozoa
pubmed:year	2002
pubmed:articleTitle	[Influence of protein kinase C on motility and acrosome reaction of sperm].
pubmed:affiliation	Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
pubmed:publicationType	Journal Article, English Abstract, Review