Linked Life Data

12477467

Source:http://linkedlifedata.com/resource/pubmed/id/12477467

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-12-12
pubmed:abstractText
In our sustained effort to understand mechanisms of mercury toxicity in fish, the histopathological effects of a 96-h acute exposure to water-borne inorganic mercury (inorganic Hg) (15 micro gL(-1)), as well as those of a single dietary dose of inorganic and methyl mercury (methyl Hg) (0.260.05 micro g.Hgg(-1) body weight), over 30 days were examined. Samples of gills, olfactory epithelium, kidneys, and liver of arctic charr, Salvelinus alpinus, were studied using light and electron microscopy. The distribution of dietary inorganic and methyl Hg in the intestinal epithelium was determined using 203Hg microautoradiography. Gills of fish exposed to water-borne inorganic Hg presented a severe disorganization of epithelial cells after 12h and modifications of cilia of ciliated olfactory cells appeared after 24h. Nevertheless, a partial recovery was seen in both tissues by the end of the 96-h exposure period. Liver was little affected by water-borne and single-trophic-dose contamination of inorganic Hg, but dietary methyl Hg had drastic effects, despite its low dosage, with severe necrosis and alterations of cytoplasmic organization. Microautoradiograms showed that inorganic Hg was distributed evenly in the intestinal epithelium, whereas methyl Hg was found at very specific locations on the epithelial surface.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0013-9351
pubmed:author
pubmed:issnType
Print
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
217-25
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Histopathological evidence of inorganic mercury and methyl mercury toxicity in the arctic charr (Salvelinus alpinus).
pubmed:affiliation
Departamento de Biologia Celular, Setor de Ciencias Biológicas, Universidade Federal do Paraná, C.P. 19031, CEP 80531-970, PR, Curitiba, Brazil. ciro@bo.ufpr.br
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't