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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
26
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pubmed:dateCreated |
2002-12-12
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pubmed:abstractText |
A series of mono and bisintercalators based on the 5,8-dihydrobenz[de]imidazo[4,5-g]isoquinoline-4,6-dione system were synthesized and evaluated for growth inhibitory properties in several human cell lines. All target compounds showed activity in the micromolar range. Representative compounds were evaluated using UV--vis spectroscopy and viscosimetric determinations, showing that they behave as DNA intercalators. Molecular modeling techniques were used in order to rationalize the moderate activity observed for bisnaphthalimides.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:AbradeloCristinaC,
pubmed-author:AceroNuriaN,
pubmed-author:BrañaMiguel FMF,
pubmed-author:CachoMónicaM,
pubmed-author:GarcíaMario AMA,
pubmed-author:LlinaresFranciscoF,
pubmed-author:Muñoz-MingarroDoloresD,
pubmed-author:RamosAnaA,
pubmed-author:Rey-StolleMaría FernandaMF,
pubmed-author:YusteMercedesM,
pubmed-author:de Pascual-TeresaBeatrizB
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pubmed:issnType |
Print
|
|
pubmed:day |
19
|
|
pubmed:volume |
45
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
5813-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12477366-Antineoplastic Agents,
pubmed-meshheading:12477366-Drug Screening Assays, Antitumor,
pubmed-meshheading:12477366-Heterocyclic Compounds with 4 or More Rings,
pubmed-meshheading:12477366-Humans,
pubmed-meshheading:12477366-Intercalating Agents,
pubmed-meshheading:12477366-Models, Molecular,
pubmed-meshheading:12477366-Naphthalenes,
pubmed-meshheading:12477366-Spectrophotometry, Ultraviolet,
pubmed-meshheading:12477366-Structure-Activity Relationship,
pubmed-meshheading:12477366-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Synthesis, antitumor activity, molecular modeling, and DNA binding properties of a new series of imidazonaphthalimides.
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pubmed:affiliation |
Departamentos de Química Orgánica y Farmacéutica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanización Montepríncipe, 28668-Boadilla del Monte, Madrid, Spain. mfbrana@ceu.es
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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