Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2002-12-11
pubmed:abstractText
Children with Wilms tumor who have a particular risk of failure at relapse or at primary diagnosis were treated with high-dose chemotherapy (HDC) and autologous peripheral blood stem cell rescue in order to improve their probability of survival. From April 1992 to December 1998, 23 evaluable patients received HDC within the German Cooperative Wilms Tumor Studies. Nineteen were given melphalan, etoposide and carboplatin (MEC); the others received different regimens. The dose of carboplatin was adjusted according to renal function. Indications for HDC were high-risk relapse in 20 patients, bone metastases in two patients and no response in one patient. Fourteen of 23 patients are alive after a median observation time of 41 months, 11 of 14 in continuous complete remission, three in CR after relapse post HDC. The estimated survival and event-free survival for these patients are 60.9% and 48.2%. Twelve children relapsed after HDC; nine of them died within 12 months and three are surviving from 20 to 33 months after relapse. The main toxicities were hematologic, mucositis and renal (tubular dysfunction; intermittent hemodialysis in one patient). There were no toxic deaths. About half of the children suffering from Wilms tumor with very unfavorable prognostic factors survive disease-free after HDC for over 3 years. Besides hematological toxicity, mucositis and infections, renal function is at risk during HDC. With dose adjustment on glomerular filtration rate, however, no permanent renal failure was observed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0268-3369
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
893-8
pubmed:dateRevised
2006-4-24
pubmed:meshHeading
pubmed-meshheading:12476282-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:12476282-Carboplatin, pubmed-meshheading:12476282-Child, pubmed-meshheading:12476282-Child, Preschool, pubmed-meshheading:12476282-Combined Modality Therapy, pubmed-meshheading:12476282-Cyclophosphamide, pubmed-meshheading:12476282-Disease-Free Survival, pubmed-meshheading:12476282-Etoposide, pubmed-meshheading:12476282-Female, pubmed-meshheading:12476282-Germany, pubmed-meshheading:12476282-Hematologic Diseases, pubmed-meshheading:12476282-Humans, pubmed-meshheading:12476282-Ifosfamide, pubmed-meshheading:12476282-Infant, pubmed-meshheading:12476282-Kidney Diseases, pubmed-meshheading:12476282-Kidney Neoplasms, pubmed-meshheading:12476282-Life Tables, pubmed-meshheading:12476282-Lung Neoplasms, pubmed-meshheading:12476282-Male, pubmed-meshheading:12476282-Melphalan, pubmed-meshheading:12476282-Peripheral Blood Stem Cell Transplantation, pubmed-meshheading:12476282-Prognosis, pubmed-meshheading:12476282-Stomatitis, pubmed-meshheading:12476282-Survival Analysis, pubmed-meshheading:12476282-Thiotepa, pubmed-meshheading:12476282-Transplantation, Autologous, pubmed-meshheading:12476282-Wilms Tumor
pubmed:year
2002
pubmed:articleTitle
High-dose chemotherapy with autologous stem cell rescue in children with nephroblastoma.
pubmed:affiliation
Department of Pediatric Hematology/Oncology, University of Essen, Germany.
pubmed:publicationType
Journal Article, Multicenter Study