Linked Life Data

12475089

Source:http://linkedlifedata.com/resource/pubmed/id/12475089

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-12-11
pubmed:abstractText
The association between the APOE gene and Alzheimer's disease and other forms of dementia has been widely documented, but its relevance as a genetic risk factor in specific ethnic groups other than Caucasians in the United States and Europe is limited. The aim of this work was to describe the distribution of the APOE genotype in 80 subjects of Spanish origin, over 60 years old, who were institutionalized in the Spanish Hospital of Mexico City. Thirty-eight subjects who met the DSM-IV and ICD-10 criteria for Alzheimer's disease or vascular dementia and 42 controls without dementia underwent genotyping. APOE epsilon allele frequencies were as follows: for affected individuals, epsilon2, 7.9%, epsilon3, 69.7%, and epsilon4, 22.4%; for controls, epsilon2, 4.8%, epsilon3, 91.6%, and epsilon4, 3.6%. The higher frequency of the epsilon4 allele in the affected group (chi2 = 14.5; df = 4, p = .006) confirms an association between this APOE molecular variant and dementia in elderly Spaniards.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1041-6102
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
291-300
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Apolipoprotein E genotypes in a group of elderly subjects of Spanish descent living in Mexico City.
pubmed:affiliation
Department of Psychiatric Genetics, Instituto Nacional de Psiquiatría Ramón de la Fuente, San Lorenzo Huipulco, México DF, México.
pubmed:publicationType
Journal Article, Review