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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-12-10
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pubmed:abstractText |
Over the last few years, a role for the brain catalase-H(2)O(2) enzymatic system has been suggested in the behavioural effects observed in rodents after ethanol administration. This role seems to be related to the ability of cerebral catalase to metabolise ethanol to acetaldehyde using H(2)O(2)as a co-substrate. On the other hand, it has been shown that normobaric hyperoxia increases the rate of cerebral H(2)O(2) production in rodents in vivo. Thus, substrate-level changes could regulate brain catalase activity, thereby modulating the behavioural effects of ethanol.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0033-3158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
165
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
51-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12474118-Amitrole,
pubmed-meshheading:12474118-Animals,
pubmed-meshheading:12474118-Brain Chemistry,
pubmed-meshheading:12474118-Caffeine,
pubmed-meshheading:12474118-Catalase,
pubmed-meshheading:12474118-Central Nervous System Stimulants,
pubmed-meshheading:12474118-Cerebral Cortex,
pubmed-meshheading:12474118-Cocaine,
pubmed-meshheading:12474118-Dopamine Uptake Inhibitors,
pubmed-meshheading:12474118-Dose-Response Relationship, Drug,
pubmed-meshheading:12474118-Enzyme Inhibitors,
pubmed-meshheading:12474118-Ethanol,
pubmed-meshheading:12474118-Hydrogen Peroxide,
pubmed-meshheading:12474118-Hyperoxia,
pubmed-meshheading:12474118-Male,
pubmed-meshheading:12474118-Mice,
pubmed-meshheading:12474118-Motor Activity,
pubmed-meshheading:12474118-Spectrophotometry,
pubmed-meshheading:12474118-Time Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Ethanol-stimulated behaviour in mice is modulated by brain catalase activity and H2O2 rate of production.
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pubmed:affiliation |
Area de Psicobiologia, Universitat Jaume I, Campus de Riv Sec., Apartat. 8029 AP, 12071 Castelló, Spain.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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