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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001792,
umls-concept:C0012155,
umls-concept:C0019904,
umls-concept:C0023775,
umls-concept:C0332281,
umls-concept:C0392756,
umls-concept:C0681850,
umls-concept:C1121571,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C1882417,
umls-concept:C2349001,
umls-concept:C2697811
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|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2002-12-10
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|
pubmed:abstractText |
The oxidative modification of LDL is considered to play a central role in the pathogenesis of atherosclerosis and coronary heart disease (CHD). Paraoxonase (PON1) protects LDL from oxidation and may therefore retard the development of atherosclerosis. The PON1-192 polymorphism is associated with diminished PON1 concentrations and an increased risk for CHD in RR-allele subjects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1436-6207
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
237-43
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12474066-Aged,
pubmed-meshheading:12474066-Antioxidants,
pubmed-meshheading:12474066-Aryldialkylphosphatase,
pubmed-meshheading:12474066-Beverages,
pubmed-meshheading:12474066-Cardiovascular Diseases,
pubmed-meshheading:12474066-Carotenoids,
pubmed-meshheading:12474066-Chromatography, High Pressure Liquid,
pubmed-meshheading:12474066-Esterases,
pubmed-meshheading:12474066-Female,
pubmed-meshheading:12474066-Gene Frequency,
pubmed-meshheading:12474066-Genotype,
pubmed-meshheading:12474066-Heterozygote,
pubmed-meshheading:12474066-Homozygote,
pubmed-meshheading:12474066-Humans,
pubmed-meshheading:12474066-Lipid Peroxidation,
pubmed-meshheading:12474066-Longitudinal Studies,
pubmed-meshheading:12474066-Lycopersicon esculentum,
pubmed-meshheading:12474066-Male,
pubmed-meshheading:12474066-Middle Aged,
pubmed-meshheading:12474066-Oxidation-Reduction,
pubmed-meshheading:12474066-Polymorphism, Genetic,
pubmed-meshheading:12474066-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:12474066-beta Carotene
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pubmed:year |
2002
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|
pubmed:articleTitle |
Paraoxonase 1 Q192R (PON1-192) polymorphism is associated with reduced lipid peroxidation in R-allele-carrier but not in QQ homozygous elderly subjects on a tomato-rich diet.
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|
pubmed:affiliation |
Federal Research Centre for Nutrition, Institute of Nutritional Physiology, Haid-und-Neu-Str. 9, 76131 Karlsruhe, Germany. achim.bub@bfe.uni-karlsruhe.de
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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