|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006812,
umls-concept:C0027651,
umls-concept:C0086418,
umls-concept:C0205314,
umls-concept:C0441655,
umls-concept:C0441833,
umls-concept:C0449774,
umls-concept:C0520484,
umls-concept:C0679622,
umls-concept:C0969276,
umls-concept:C1999270
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|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2002-12-10
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|
pubmed:abstractText |
ST1481 is the lead compound of a novel series of 7-modified camptothecins, the 7-oxyimino methyl derivatives, characterized by potent topoisomerase I inhibition and cytotoxic activity. Based on its therapeutic efficacy in a human non-small cell lung carcinoma model and its favorable pharmacological profile, the novel analogue was selected for further preclinical development.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Dec
|
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:CareniniNivesN,
pubmed-author:CarminatiPaoloP,
pubmed-author:CuccoCarlaC,
pubmed-author:De CesareMichelandreaM,
pubmed-author:MerliniLucioL,
pubmed-author:PencoSergioS,
pubmed-author:PeregoPaolaP,
pubmed-author:PisanoClaudioC,
pubmed-author:PratesiGraziellaG,
pubmed-author:RighettiSabina CSC,
pubmed-author:VesciLoredanaL,
pubmed-author:ZuninoFrancoF
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|
pubmed:issnType |
Print
|
|
pubmed:volume |
8
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
3904-9
|
|
pubmed:dateRevised |
2010-11-18
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|
pubmed:meshHeading |
pubmed-meshheading:12473606-Administration, Oral,
pubmed-meshheading:12473606-Animals,
pubmed-meshheading:12473606-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:12473606-Camptothecin,
pubmed-meshheading:12473606-Cell Cycle,
pubmed-meshheading:12473606-Cell Division,
pubmed-meshheading:12473606-Drug Resistance, Neoplasm,
pubmed-meshheading:12473606-Drug Screening Assays, Antitumor,
pubmed-meshheading:12473606-Enzyme Inhibitors,
pubmed-meshheading:12473606-Female,
pubmed-meshheading:12473606-Humans,
pubmed-meshheading:12473606-Mice,
pubmed-meshheading:12473606-Mice, Nude,
pubmed-meshheading:12473606-Neoplasms, Experimental,
pubmed-meshheading:12473606-Topoisomerase I Inhibitors,
pubmed-meshheading:12473606-Topotecan,
pubmed-meshheading:12473606-Tumor Cells, Cultured,
pubmed-meshheading:12473606-Xenograft Model Antitumor Assays
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pubmed:year |
2002
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|
pubmed:articleTitle |
Pattern of antitumor activity of a novel camptothecin, ST1481, in a large panel of human tumor xenografts.
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|
pubmed:affiliation |
Istituto Nazionale Tumori, 20133 Milan, Italy. graziella.pratesi@istitutotumori.mi.it
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
