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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2002-12-10
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pubmed:abstractText |
Early-stage adenocarcinoma of the rectum treated with curative intent has a favorable overall prognosis; however, 20%-30% of the patients recur, and the majority ultimately die of disease. Recurrence and tumor-related mortality may be attributable to molecular abnormalities in primary tumors accounting for their more aggressive biological behavior. This study evaluates such molecular phenotypes with regard to cell cycle regulation and proliferation and determines their significance for patient outcome.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/Ki-67 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/MDM2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-mdm2,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3841-9
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:12473598-Adenocarcinoma,
pubmed-meshheading:12473598-Adult,
pubmed-meshheading:12473598-Aged,
pubmed-meshheading:12473598-Aged, 80 and over,
pubmed-meshheading:12473598-Cell Cycle Proteins,
pubmed-meshheading:12473598-Cyclin D1,
pubmed-meshheading:12473598-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:12473598-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:12473598-Cyclins,
pubmed-meshheading:12473598-Disease-Free Survival,
pubmed-meshheading:12473598-Female,
pubmed-meshheading:12473598-Humans,
pubmed-meshheading:12473598-Immunoenzyme Techniques,
pubmed-meshheading:12473598-Ki-67 Antigen,
pubmed-meshheading:12473598-Male,
pubmed-meshheading:12473598-Middle Aged,
pubmed-meshheading:12473598-Neoplasm Proteins,
pubmed-meshheading:12473598-Nuclear Proteins,
pubmed-meshheading:12473598-Protein Array Analysis,
pubmed-meshheading:12473598-Proto-Oncogene Proteins,
pubmed-meshheading:12473598-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:12473598-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:12473598-Rectal Neoplasms,
pubmed-meshheading:12473598-Tumor Markers, Biological,
pubmed-meshheading:12473598-Tumor Suppressor Protein p53,
pubmed-meshheading:12473598-Tumor Suppressor Proteins
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pubmed:year |
2002
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pubmed:articleTitle |
Tissue microarray molecular profiling of early, node-negative adenocarcinoma of the rectum: a comprehensive analysis.
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pubmed:affiliation |
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
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pubmed:publicationType |
Journal Article
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