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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2002-12-10
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pubmed:abstractText |
The p16(INK4A) tumor suppressor gene is inactivated in many solid tumors, including non-small cell lung cancers (NSCLCs), through promoter hypermethylation. Presence of p16(INK4A) hypermethylation in precursor lesions of NSCLC and in body fluids of individuals at risk makes it a potential candidate for early disease detection. However, the current low sensitivity of p16(INK4A) hypermethylation detection in plasma limits its consideration in a diagnostic grid.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3782-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12473590-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:12473590-Chromosomes, Human, Pair 3,
pubmed-meshheading:12473590-Cohort Studies,
pubmed-meshheading:12473590-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:12473590-DNA, Neoplasm,
pubmed-meshheading:12473590-DNA Methylation,
pubmed-meshheading:12473590-Female,
pubmed-meshheading:12473590-Genes, ras,
pubmed-meshheading:12473590-Humans,
pubmed-meshheading:12473590-Lung Neoplasms,
pubmed-meshheading:12473590-Male,
pubmed-meshheading:12473590-Microsatellite Repeats,
pubmed-meshheading:12473590-Middle Aged,
pubmed-meshheading:12473590-Neoplasm Staging,
pubmed-meshheading:12473590-Polymerase Chain Reaction,
pubmed-meshheading:12473590-Promoter Regions, Genetic,
pubmed-meshheading:12473590-Prospective Studies,
pubmed-meshheading:12473590-Survival Rate,
pubmed-meshheading:12473590-Tumor Cells, Cultured,
pubmed-meshheading:12473590-Tumor Markers, Biological
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pubmed:year |
2002
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pubmed:articleTitle |
p16(INK4A) Hypermethylation detected by fluorescent methylation-specific PCR in plasmas from non-small cell lung cancer.
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pubmed:affiliation |
Department of Experimental Oncology, Unit 10, Istituto Nazionale Tumori, 20133 Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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