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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2002-12-10
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pubmed:abstractText |
The activities of insulin-like growth factors (IGFs) in regulating cell proliferation,differentiation, and apoptosis are modulated by a family of high-affinity specific IGF-binding proteins (IGFBPs), especially IGFBP-3, the most abundant IGFBP in circulation. Hypermethylation of the promoter represses the expression of the IGFBP-3 gene. The purpose of this study was to determine whether the methylation status of IGFBP-3 promoter influences the prognosis of non-small cell lung cancer (NSCLC).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3669-75
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12473575-Adenocarcinoma,
pubmed-meshheading:12473575-Aged,
pubmed-meshheading:12473575-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:12473575-Cell Differentiation,
pubmed-meshheading:12473575-DNA, Neoplasm,
pubmed-meshheading:12473575-DNA Methylation,
pubmed-meshheading:12473575-DNA Primers,
pubmed-meshheading:12473575-Female,
pubmed-meshheading:12473575-Humans,
pubmed-meshheading:12473575-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:12473575-Lung Neoplasms,
pubmed-meshheading:12473575-Male,
pubmed-meshheading:12473575-Middle Aged,
pubmed-meshheading:12473575-Neoplasm Staging,
pubmed-meshheading:12473575-Polymerase Chain Reaction,
pubmed-meshheading:12473575-Prognosis,
pubmed-meshheading:12473575-Promoter Regions, Genetic,
pubmed-meshheading:12473575-Smoking,
pubmed-meshheading:12473575-Survival Rate
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pubmed:year |
2002
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pubmed:articleTitle |
Correlation between insulin-like growth factor-binding protein-3 promoter methylation and prognosis of patients with stage I non-small cell lung cancer.
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pubmed:affiliation |
Department of Thoracic/Head, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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