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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-12-20
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pubmed:abstractText |
The mechanism controlling the development of dopaminergic (DA) and serotonergic (5HT) neurons in vertebrates is not well understood. Here we characterized a zebrafish mutant--too few (tof)--that develops hindbrain 5HT and noradrenergic neurons, but does not develop hypothalamic DA and 5HT neurons. tof encodes a forebrain-specific zinc finger transcription repressor that is homologous to the mammalian Fezl (forebrain embryonic zinc finger-like protein). Mosaic and co-staining analyses showed that fezl was not expressed in DA or 5HT neurons and instead controlled development of these neurons non-cell-autonomously. Both the eh1-related repressor motif and the second zinc finger domain were necessary for tof function. Our results indicate that tof/fezl is a key component in regulating the development of monoaminergic neurons in the vertebrate brain.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1097-6256
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
28-33
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12469125-Animals,
pubmed-meshheading:12469125-Anti-Bacterial Agents,
pubmed-meshheading:12469125-Apoptosis,
pubmed-meshheading:12469125-Biogenic Monoamines,
pubmed-meshheading:12469125-Brain,
pubmed-meshheading:12469125-Brain Tissue Transplantation,
pubmed-meshheading:12469125-Carrier Proteins,
pubmed-meshheading:12469125-Cell Differentiation,
pubmed-meshheading:12469125-Chromosome Mapping,
pubmed-meshheading:12469125-Dopamine,
pubmed-meshheading:12469125-Embryo, Nonmammalian,
pubmed-meshheading:12469125-Female,
pubmed-meshheading:12469125-Gene Expression Regulation, Developmental,
pubmed-meshheading:12469125-Male,
pubmed-meshheading:12469125-Neurons,
pubmed-meshheading:12469125-Peptides,
pubmed-meshheading:12469125-Repressor Proteins,
pubmed-meshheading:12469125-Serotonin,
pubmed-meshheading:12469125-Signal Transduction,
pubmed-meshheading:12469125-Stem Cells,
pubmed-meshheading:12469125-Zebrafish,
pubmed-meshheading:12469125-Zebrafish Proteins,
pubmed-meshheading:12469125-Zinc Fingers
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pubmed:year |
2003
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pubmed:articleTitle |
Zinc finger protein too few controls the development of monoaminergic neurons.
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pubmed:affiliation |
Rinat Neuroscience Corporation, 3155 Porter Drive, Palo Alto, California 94304, USA. gillev@rinatneuro.com
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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