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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2002-12-6
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pubmed:abstractText |
Studies indicate that thrombin plays an important role in intracerebral hemorrhage (ICH)-induced edema formation. Although thrombin is produced as the blood clots, it may be bound to fibrin and only gradually released from the clot. The time window for administration of a thrombin inhibitor to reduce ICH-induced edema is unknown. Whether this time window extends beyond the period when a thrombin inhibitor might exacerbate rebleeding is also unknown.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1524-4628
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3012-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12468805-Animals,
pubmed-meshheading:12468805-Antithrombins,
pubmed-meshheading:12468805-Brain,
pubmed-meshheading:12468805-Brain Chemistry,
pubmed-meshheading:12468805-Brain Edema,
pubmed-meshheading:12468805-Cerebral Hemorrhage,
pubmed-meshheading:12468805-Disease Models, Animal,
pubmed-meshheading:12468805-Dose-Response Relationship, Drug,
pubmed-meshheading:12468805-Drug Administration Schedule,
pubmed-meshheading:12468805-Hemoglobins,
pubmed-meshheading:12468805-Infusions, Parenteral,
pubmed-meshheading:12468805-Male,
pubmed-meshheading:12468805-Microinjections,
pubmed-meshheading:12468805-Pipecolic Acids,
pubmed-meshheading:12468805-Rats,
pubmed-meshheading:12468805-Rats, Sprague-Dawley,
pubmed-meshheading:12468805-Stereotaxic Techniques,
pubmed-meshheading:12468805-Time Factors,
pubmed-meshheading:12468805-Treatment Outcome,
pubmed-meshheading:12468805-Water
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pubmed:year |
2002
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pubmed:articleTitle |
Delayed argatroban treatment reduces edema in a rat model of intracerebral hemorrhage.
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pubmed:affiliation |
Department of Neurosurgery, University of Michigan, Ann Arbor, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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