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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2002-12-6
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pubmed:abstractText |
Endothelial nitric oxide synthase (eNOS) activity is decreased after subarachnoid hemorrhage (SAH). Simvastatin increases eNOS activity. We hypothesized that simvastatin would increase eNOS protein and ameliorate SAH-induced cerebral vasospasm.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1524-4628
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2950-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12468796-Animals,
pubmed-meshheading:12468796-Brain,
pubmed-meshheading:12468796-Disease Models, Animal,
pubmed-meshheading:12468796-Endothelium, Vascular,
pubmed-meshheading:12468796-Enzyme Activation,
pubmed-meshheading:12468796-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:12468796-Injections, Subcutaneous,
pubmed-meshheading:12468796-Male,
pubmed-meshheading:12468796-Mice,
pubmed-meshheading:12468796-Mice, Inbred C57BL,
pubmed-meshheading:12468796-Middle Cerebral Artery,
pubmed-meshheading:12468796-Nitric Oxide Synthase,
pubmed-meshheading:12468796-Nitric Oxide Synthase Type II,
pubmed-meshheading:12468796-Nitric Oxide Synthase Type III,
pubmed-meshheading:12468796-Simvastatin,
pubmed-meshheading:12468796-Subarachnoid Hemorrhage,
pubmed-meshheading:12468796-Time Factors,
pubmed-meshheading:12468796-Up-Regulation,
pubmed-meshheading:12468796-Vascular Patency,
pubmed-meshheading:12468796-Vasospasm, Intracranial
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pubmed:year |
2002
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pubmed:articleTitle |
Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage.
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pubmed:affiliation |
Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Duke University School of Medicine Duke University Medical Center, Durham, NC, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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