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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2002-12-6
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pubmed:abstractText |
The 14-amino-acid peptide bombesin (BN) has a high affinity for the gastrin-releasing peptide (GRP) receptor that is expressed by a variety of tumors. Recently, high densities of GRP receptors were identified by in vitro receptor autoradiography in human prostate and breast carcinomas using [(125)I-Tyr(4)]BN as radioligand. Radiometal-labeled diethylenetriaminepentaacetic acid (DTPA)-BN derivatives are potentially useful radioligands for receptor-targeted scintigraphy and radiotherapy of GRP receptor-expressing tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0161-5505
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1650-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12468515-Amino Acid Sequence,
pubmed-meshheading:12468515-Animals,
pubmed-meshheading:12468515-Bombesin,
pubmed-meshheading:12468515-Indium Radioisotopes,
pubmed-meshheading:12468515-Male,
pubmed-meshheading:12468515-Molecular Sequence Data,
pubmed-meshheading:12468515-Pentetic Acid,
pubmed-meshheading:12468515-Radiopharmaceuticals,
pubmed-meshheading:12468515-Rats,
pubmed-meshheading:12468515-Receptors, Bombesin,
pubmed-meshheading:12468515-Tissue Distribution
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pubmed:year |
2002
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pubmed:articleTitle |
Preclinical comparison of (111)In-labeled DTPA- or DOTA-bombesin analogs for receptor-targeted scintigraphy and radionuclide therapy.
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pubmed:affiliation |
Department of Nuclear Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands. breeman@nuge.azr.nl
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pubmed:publicationType |
Journal Article,
Comparative Study
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