Linked Life Data

12467921

Source:http://linkedlifedata.com/resource/pubmed/id/12467921

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-12-6
pubmed:abstractText
A chemiluminescent method for the determination of isoniazid is described. Method is based on the chemiluminescence (CL) generated during the oxidation of luminol by N-bromosuccinimide (NBS) and N-chlorosuccinimide (NCS) in alkaline medium. It was found that the isoniazid could greatly enhance this CL intensity when present in the luminol solution. Based on this observation, a new flow-injection CL method for the determination of isoniazid is proposed in this paper. The detection limits were 4 and 3 ng ml(-1) isoniazid for the NBS- and NCS-luminol CL systems, respectively. The relative CL intensity was linear with the isoniazid concentration in the range of 8-600 and 600-5000 ng ml(-1) for the NBS-luminol CL system, and 6-200 and 200-2000 ng ml(-1) for the NCS-luminol CL system. The results obtained for the assay of pharmaceutical preparations compared well with those obtained by the official method and demonstrated good accuracy and precision.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0731-7085
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1499-506
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Flow injection determination of isoniazid using N-bromosuccinimide- and N-chlorosuccinimide-luminol chemiluminescence systems.
pubmed:affiliation
Department of Chemistry, Faculty of Sciences, Shiraz University, Shiraz, Iran. safavi@chem.susc.ac.ir
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't