rdf:type |
|
lifeskim:mentions |
umls-concept:C0006864,
umls-concept:C0022203,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0205314,
umls-concept:C0597357,
umls-concept:C0679622,
umls-concept:C0965636,
umls-concept:C1172779,
umls-concept:C1334043,
umls-concept:C1704675
|
pubmed:issue |
1
|
pubmed:dateCreated |
2002-12-6
|
pubmed:abstractText |
Two regioisomers and 13 analogues of the putative endocannabinoid noladin ether (2-arachidonyl glyceryl ether, 2-AGE, 1) were synthesized and tested for their interaction with CB(1) receptors in rat brain membranes. The results showed that a C-20 tetra-unsaturated moiety is necessary for high affinity, and that a series of alkyl glyceryl ethers of potential occurrence in brain tissues have less affinity than 2-AGE for CB(1) receptors.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0960-894X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
6
|
pubmed:volume |
13
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
43-6
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:12467613-Animals,
pubmed-meshheading:12467613-Brain,
pubmed-meshheading:12467613-Cell Membrane,
pubmed-meshheading:12467613-Endocannabinoids,
pubmed-meshheading:12467613-Fatty Acids, Unsaturated,
pubmed-meshheading:12467613-Glycerides,
pubmed-meshheading:12467613-Protein Binding,
pubmed-meshheading:12467613-Radioligand Assay,
pubmed-meshheading:12467613-Rats,
pubmed-meshheading:12467613-Receptors, Cannabinoid,
pubmed-meshheading:12467613-Receptors, Drug,
pubmed-meshheading:12467613-Stereoisomerism,
pubmed-meshheading:12467613-Structure-Activity Relationship
|
pubmed:year |
2003
|
pubmed:articleTitle |
Homologues and isomers of noladin ether, a putative novel endocannabinoid: interaction with rat cannabinoid CB(1) receptors.
|
pubmed:affiliation |
DiSCAFF, Viale Ferrucci 33, 28100 Novara, Italy. appendin@pharm.unito.it
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|