Source:http://linkedlifedata.com/resource/pubmed/id/12466256
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
899
|
| pubmed:dateCreated |
2002-12-5
|
| pubmed:abstractText |
Evaluation of tumour size modifications in response to treatment is a critical issue in the management of advanced malignancies. In 1981, the World Health Organization (WHO) established guidelines for tumour response assessment. These WHO1981 criteria were recently simplified in a revised version, named RECIST (Response Evaluation Criteria in Solid Tumours), which uses unidimensional instead of bidimensional measurements, a reduced number of measured lesions, withdrawal of the progression criteria based on isolated increase of a single lesion, and different shrinkage threshold for definitions of tumour response and progression. In order to validate these new guidelines, we have compared results obtained with both classifications in a prospective series of 91 patients receiving chemotherapy for metastatic colorectal cancer. Data from iterative tomographic measurements were fully recorded and reviewed by an expert panel. The overall response and progression rates according to the WHO1981 criteria were 19% and 58%, respectively. Using RECIST criteria, 16 patients were reclassified in a more favourable subgroup, the overall response rate being 28% and the progression rate 45% (non-weighted kappa concordance test 0.72). When isolated increase of a single measurable lesion is not taken into account for progression with the WHO1981 criteria, only 7 patients were reclassified and the kappa test was satisfying, i.e. > or =0.75, for the whole population as well as for each of the responding and progressive subgroups. Since it provides concordant results with a simplified method, the use of RECIST criteria is recommended for evaluation of treatment efficacy in clinical trials and routine practice.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0007-1285
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| pubmed:author |
pubmed-author:BarbierYY,
pubmed-author:BleuseJ PJP,
pubmed-author:BoyerJ DJD,
pubmed-author:ChapuisFF,
pubmed-author:ChassignolLL,
pubmed-author:DesseigneFF,
pubmed-author:FondAA,
pubmed-author:FreyerGG,
pubmed-author:GaudinJ LJL,
pubmed-author:GouttebelM CMC,
pubmed-author:HedeliusFF,
pubmed-author:HeilmannM OMO,
pubmed-author:KaemmerlenPP,
pubmed-author:LledoGG,
pubmed-author:Lombard-BohasCC,
pubmed-author:MackiewiczRR,
pubmed-author:MoindrotHH,
pubmed-author:MoraillonAA,
pubmed-author:MorganH RHR,
pubmed-author:PelletOO,
pubmed-author:StremsdoerferNN,
pubmed-author:Trillet-LenoirVV,
pubmed-author:ValetteP JPJ
|
| pubmed:issnType |
Print
|
| pubmed:volume |
75
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
903-8
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12466256-Adenocarcinoma,
pubmed-meshheading:12466256-Aged,
pubmed-meshheading:12466256-Antineoplastic Agents,
pubmed-meshheading:12466256-Colorectal Neoplasms,
pubmed-meshheading:12466256-Disease Progression,
pubmed-meshheading:12466256-Female,
pubmed-meshheading:12466256-Health Status Indicators,
pubmed-meshheading:12466256-Humans,
pubmed-meshheading:12466256-Male,
pubmed-meshheading:12466256-Middle Aged,
pubmed-meshheading:12466256-Practice Guidelines as Topic,
pubmed-meshheading:12466256-Prospective Studies,
pubmed-meshheading:12466256-Survival Rate,
pubmed-meshheading:12466256-Treatment Outcome
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Assessment of tumour response to chemotherapy for metastatic colorectal cancer: accuracy of the RECIST criteria.
|
| pubmed:affiliation |
Department of Medical Oncology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, 69495 Pierre Bénite, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Validation Studies
|