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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
25
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pubmed:dateCreated |
2002-12-5
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pubmed:abstractText |
[reaction: see text] A free porphyrin coupled on 2-deoxy-D-ribose was synthesized and incorporated into DNA via phosphoramidite chemistry. Substitution at the ends of a 5'-modified self-complementary duplex was found to be thermally and thermodynamically stabilizing. The porphyrin moiety strongly intercalates in the duplex when located near the center, and retains its fluorescence properties in DNA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1523-7060
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4377-80
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12465891-Base Sequence,
pubmed-meshheading:12465891-Circular Dichroism,
pubmed-meshheading:12465891-DNA,
pubmed-meshheading:12465891-Fluorescence,
pubmed-meshheading:12465891-Intercalating Agents,
pubmed-meshheading:12465891-Molecular Structure,
pubmed-meshheading:12465891-Nucleic Acid Conformation,
pubmed-meshheading:12465891-Nucleosides,
pubmed-meshheading:12465891-Porphyrins,
pubmed-meshheading:12465891-Temperature,
pubmed-meshheading:12465891-Thermodynamics
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pubmed:year |
2002
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pubmed:articleTitle |
A porphyrin C-nucleoside incorporated into DNA.
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pubmed:affiliation |
Department of Chemistry, Stanford University, California 94305-5080, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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