|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2002-12-4
|
|
pubmed:abstractText |
We have previously demonstrated that CpG oligodeoxynucleotides (CpG-ODNs) protect against eosinophilia and airway hyperresponsiveness in murine models of allergen-induced asthma. Acute inflammation is hypothesized to induce chronic airway responses, but no previous studies have evaluated the effects of CpG-ODNs on allergen-induced airway remodeling. Because remodeling is thought to be responsible for many of the long-term adverse effects on asthmatic patients, we evaluated whether CpG-ODNs might similarly prevent these changes using a murine model of recurrent allergen exposure.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0091-6749
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
110
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
867-72
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:12464952-Animals,
pubmed-meshheading:12464952-Asthma,
pubmed-meshheading:12464952-Bronchi,
pubmed-meshheading:12464952-Bronchial Hyperreactivity,
pubmed-meshheading:12464952-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:12464952-Chronic Disease,
pubmed-meshheading:12464952-Collagen,
pubmed-meshheading:12464952-Disease Models, Animal,
pubmed-meshheading:12464952-Eosinophilia,
pubmed-meshheading:12464952-Female,
pubmed-meshheading:12464952-Fibrosis,
pubmed-meshheading:12464952-Immunoglobulin E,
pubmed-meshheading:12464952-Mice,
pubmed-meshheading:12464952-Mice, Inbred C57BL,
pubmed-meshheading:12464952-Oligodeoxyribonucleotides,
pubmed-meshheading:12464952-Transforming Growth Factor beta
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma.
|
|
pubmed:affiliation |
Department of Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
