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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2002-12-4
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pubmed:abstractText |
Sindbis virus, a blood-borne virus transmitted by mosquitoes, has been used as a vector to efficiently express exogenous genes in vitro and in vivo and to induce apoptosis. Because Sindbis virus infects mammalian cells by interacting with the high-affinity laminin receptors, which are expressed at higher levels in several human cancers than in normal cells, we determined whether a Sindbis viral vector could be used to target cancers in vivo.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8874
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1790-802
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12464651-Animals,
pubmed-meshheading:12464651-Antineoplastic Agents,
pubmed-meshheading:12464651-Apoptosis,
pubmed-meshheading:12464651-Cricetinae,
pubmed-meshheading:12464651-Factor VIII,
pubmed-meshheading:12464651-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:12464651-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12464651-Genetic Vectors,
pubmed-meshheading:12464651-Humans,
pubmed-meshheading:12464651-Immunohistochemistry,
pubmed-meshheading:12464651-In Situ Nick-End Labeling,
pubmed-meshheading:12464651-Injections, Intraperitoneal,
pubmed-meshheading:12464651-Killer Cells, Natural,
pubmed-meshheading:12464651-Lac Operon,
pubmed-meshheading:12464651-Mice,
pubmed-meshheading:12464651-Mice, SCID,
pubmed-meshheading:12464651-Neoplasms,
pubmed-meshheading:12464651-Replicon,
pubmed-meshheading:12464651-Sindbis Virus,
pubmed-meshheading:12464651-Transfection,
pubmed-meshheading:12464651-Transplantation, Heterologous,
pubmed-meshheading:12464651-Tumor Cells, Cultured,
pubmed-meshheading:12464651-Tumor Markers, Biological,
pubmed-meshheading:12464651-beta-Galactosidase
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pubmed:year |
2002
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pubmed:articleTitle |
In vivo antitumor activity of Sindbis viral vectors.
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pubmed:affiliation |
NYU Cancer Institute, Rita J. and Stanley H. Kaplan Comprehensive Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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