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pubmed-article:12464557pubmed:abstractTextVitamin A derivatives are widely used therapeutic agents for the treatment of dermatological and rheumatological disorders. Long-standing administration of these drugs, in turn, causes skeletal changes including ossification of ligaments, premature fusion of epiphyses and abnormalities of modeling. Recent in vitro experiments have further suggested that retinoid treatment of cultured chondrocytes may cause apoptotic cell death. The present study aims to address detailed cartilage changes associated with in vivo administration of vitamin A derivatives.lld:pubmed
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pubmed-article:12464557pubmed:authorpubmed-author:MatsusueYYlld:pubmed
pubmed-article:12464557pubmed:copyrightInfoCopyright 2002 OsteoArthritis Research Society International. Published by Elsevier Science Ltd.lld:pubmed
pubmed-article:12464557pubmed:issnTypePrintlld:pubmed
pubmed-article:12464557pubmed:volume10lld:pubmed
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pubmed-article:12464557pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12464557pubmed:articleTitleArticular cartilage degradation and de-differentiation of chondrocytes by the systemic administration of retinyl acetate-ectopic production of osteoblast stimulating factor-1 by chondrocytes in mice.lld:pubmed
pubmed-article:12464557pubmed:affiliationDepartment of Orthopaedic Surgery, Shiga University of Medical Science, Setatsukinowa-cho, Otsu-shi, Shiga-ken, 520-2192, Japan.lld:pubmed
pubmed-article:12464557pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12464557pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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