Linked Life Data

12464557

Source:http://linkedlifedata.com/resource/pubmed/id/12464557

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2002-12-4
pubmed:abstractText
Vitamin A derivatives are widely used therapeutic agents for the treatment of dermatological and rheumatological disorders. Long-standing administration of these drugs, in turn, causes skeletal changes including ossification of ligaments, premature fusion of epiphyses and abnormalities of modeling. Recent in vitro experiments have further suggested that retinoid treatment of cultured chondrocytes may cause apoptotic cell death. The present study aims to address detailed cartilage changes associated with in vivo administration of vitamin A derivatives.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1063-4584
pubmed:author
pubmed:copyrightInfo
Copyright 2002 OsteoArthritis Research Society International. Published by Elsevier Science Ltd.
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
968-76
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Articular cartilage degradation and de-differentiation of chondrocytes by the systemic administration of retinyl acetate-ectopic production of osteoblast stimulating factor-1 by chondrocytes in mice.
pubmed:affiliation
Department of Orthopaedic Surgery, Shiga University of Medical Science, Setatsukinowa-cho, Otsu-shi, Shiga-ken, 520-2192, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't