Linked Life Data

12464363

Source:http://linkedlifedata.com/resource/pubmed/id/12464363

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2002-12-4
pubmed:abstractText
The effects of evodiamine on gastric emptying, gastrointestinal transit, and plasma levels of cholecystokinin (CCK) were studied in male rats. Evodiamine, isolated from the dry unripened fruit of Evodia rutaecarpa Bentham (a Chinese medicine named Wu-chu-yu), has been recommended for abdominal pain, acid regurgitation, nausea, diarrhea, and dysmenorrhea. Gastrointestinal motility was assessed in rats 15 min after intragastric instillation of a test meal containing charcoal and Na(2)51CrO(4). Gastric emptying was determined by measuring the amount of radiolabeled chromium contained in the small intestine as a percentage of the initial amount received. Gastrointestinal transit was evaluated by calculating the geometric center of distribution of the radiolabeled marker. Blood samples were collected for CCK radioimmunoassay (RIA). After administration of evodiamine (0.67-6.00 mg/kg), both gastric emptying and gastrointestinal transit were inhibited, whereas the plasma concentration of CCK was increased in a dose-dependent manner. The selective CCK(1) receptor antagonists, devazepide and lorglumide, effectively attenuated the evodiamine-induced inhibition of gastric emptying and gastrointestinal transit. L-365,260 (3R-(+)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-yl)-N'-(3-methylphenyl)-urea), a selective CCK(2) receptor antagonist, did not alter the evodiamine-induced inhibition of gastric emptying and gastrointestinal transit. These results suggest that evodiamine inhibits both gastric emptying and gastrointestinal transit in male rats via a mechanism involving CCK release and CCK(1) receptor activation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
457
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-76
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12464363-Animals, pubmed-meshheading:12464363-Benzodiazepinones, pubmed-meshheading:12464363-Cholecystokinin, pubmed-meshheading:12464363-Devazepide, pubmed-meshheading:12464363-Gastric Emptying, pubmed-meshheading:12464363-Gastrointestinal Motility, pubmed-meshheading:12464363-Gastrointestinal Transit, pubmed-meshheading:12464363-Injections, Intraperitoneal, pubmed-meshheading:12464363-Male, pubmed-meshheading:12464363-Phenylurea Compounds, pubmed-meshheading:12464363-Plant Extracts, pubmed-meshheading:12464363-Quinazolines, pubmed-meshheading:12464363-Rats, pubmed-meshheading:12464363-Rats, Sprague-Dawley, pubmed-meshheading:12464363-Receptor, Cholecystokinin A, pubmed-meshheading:12464363-Receptor, Cholecystokinin B, pubmed-meshheading:12464363-Receptors, Cholecystokinin
pubmed:year
2002
pubmed:articleTitle
Effects of evodiamine on gastrointestinal motility in male rats.
pubmed:affiliation
Department of Physiology, School of Medicine, National Yang-Ming University, Shih-Pai, Taipei 11221, Taiwan, ROC.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't