GENERIC 12459684

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006400, umls-concept:C0034693, umls-concept:C0034721, umls-concept:C0043227, umls-concept:C0205373, umls-concept:C0444498, umls-concept:C0600688, umls-concept:C1261322, umls-concept:C1521827, umls-concept:C1549542, umls-concept:C1563350, umls-concept:C1563351
pubmed:dateCreated	2002-12-2
pubmed:abstractText	The inadvertent systemic administration of bupivacaine has been associated with fatal cardiovascular collapse. Systemic bupivacaine may affect neural control of the cardiovascular system in addition to having toxic actions on the heart. The study tested the hypothesis that systemic bupivacaine has toxic effects on brainstem cardiorespiratory control.
pubmed:language	eng
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Local, http://linkedlifedata.com/resource/pubmed/chemical/Bupivacaine
pubmed:status	MEDLINE
pubmed:author	pubmed-author:HeadleyP MaxPM, pubmed-author:PatonJulian F RJF, pubmed-author:PickeringAnthony EAE, pubmed-author:WakiHidefumiH
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1550-6
pubmed:dateRevised	2007-11-15
pubmed:articleTitle	Investigation of systemic bupivacaine toxicity using the in situ perfused working heart-brainstem preparation of the rat.
pubmed:affiliation	Sir Humphry Davy Department of Anaesthesia, Royal Infirmary, University of Bristol, Bristol BS2 8HW, UK. Tony.Pickering@Bristol.ac.uk