Source:http://linkedlifedata.com/resource/pubmed/id/12459518
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2002-12-2
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| pubmed:abstractText |
An insertional (460-461InsA) mutation in the ferritin light polypeptide (FTL) gene was recently reported in some patients with a familial form of basal ganglia degeneration with varying extrapyramidal manifestations. Some of the affected family members presented with a phenotype indistinguishable from typical Parkinson's disease (PD). In this study, 253 patients with a clinical diagnosis of idiopathic PD were screened for the insertion in the FTL gene by polymerase chain reaction-restriction fragment length polymorphism method. The results showed that none of them had the mutation, indicating that genetic defects in the FTL gene are unlikely to be a common cause of typical PD, at least in a North America population.
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| pubmed:language |
eng
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| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:author | |
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
144-6
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| pubmed:dateRevised |
2010-11-18
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| pubmed:articleTitle |
Screening of ferritin light polypeptide 460-461InsA mutation in Parkinson's disease patients in North America.
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| pubmed:affiliation |
The Parkinson's Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA. rchen@parkinsonsinstitute.org
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