Linked Life Data

12459507

Source:http://linkedlifedata.com/resource/pubmed/id/12459507

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2002-12-2
pubmed:abstractText
Several recent studies have demonstrated a neuromodulatory role for endocannabinoids via their ability to act as retrograde inhibitors of synaptic neurotransmission. We utilized the functional hyperemic response to controlled whisker stimulation to determine whether endogenous cannabinoids modulate synaptic transmission within the primary somatosensory cortex of rats. As previously demonstrated, whisker-stimulation resulted in a robust hyperemic response measured using laser Doppler flowmetry within the whisker barrel cortex. Administration of the CB(1) receptor antagonist, SR141716 (1 mg/kg i.v.), significantly potentiated the functional hyperemic response to whisker-stimulation, while having no effect on basal blood flow within the whisker barrel cortex. These data suggest that suppression of endogenous cannabinergic neurotransmission results in increased cortical activity in response to physiological sensory stimulation.
pubmed:grant
pubmed:language
eng
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:author
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-8
pubmed:dateRevised
2007-11-14
pubmed:articleTitle
The CB1 receptor antagonist SR141716 enhances stimulus-induced activation of the primary somatosensory cortex of the rat.
pubmed:affiliation
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53223, USA.