Linked Life Data

12458735

Source:http://linkedlifedata.com/resource/pubmed/id/12458735

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2002-12-2
pubmed:abstractText
Stereoisomeric uridylyl(3',5')uridines D,L-UpU and L,D-UpU were synthesised. Their cleavage was followed in the presence of acid, base and metal ion catalysts to study whether the stereochemistry affects the inherent reactivity of the internucleosidic phosphodiester bond, and whether the low molecular weight catalysts can distinguish between the substrates. The rate constants obtained were compared to those of D,D-UpU. The comparison shows that the stability of the phosphodiester bond does not depend on the stereochemistry of the sugar rings. In contrast slight reactivity differences are observed in the presence of metal ion catalysts, which suggests that selective cleavage of stereoisomeric substrates even by small molecular weight chemical catalysts may be possible.
pubmed:language
eng
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:author
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-10
pubmed:dateRevised
2006-11-15
pubmed:articleTitle
A comparative study on the cleavage of stereoisomeric uridylyl(3',5')uridines [D,D-, D,L- and L,D-UpU] by acid, base and metal ion catalysts.
pubmed:affiliation
Department of Chemistry, University of Turku, Finland. satu.mikkola@utu.fi