Linked Life Data

12447480

Source:http://linkedlifedata.com/resource/pubmed/id/12447480

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2002-11-26
pubmed:abstractText
We measured the content of glutathione and activity of glutathione-metabolizing and antioxidant enzymes superoxide dismutase and catalase in samples obtained from 52 patients with malignant lung tumors and 20 patients with benign lung tumors. The content of glutathione and activity of glutathione-metabolizing enzymes underwent similar changes, but these changes were most pronounced in malignant tumors. Antioxidant enzyme activity changed insignificantly in benign tumors, but significantly decreased in malignant tumors (squamous cell carcinoma and adenocarcinoma). The severity of changes in malignant tumors depended on the degree of malignancy. Most pronounced changes were observed in adenocarcinoma, which often metastasizes and is resistant to chemotherapy. These changes were least pronounced in bronchoalveolar carcinoma sensitive to chemotherapy.
pubmed:language
eng
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:author
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
606-8
pubmed:dateRevised
2006-11-15
pubmed:articleTitle
Activity of glutathione-metabolizing and antioxidant enzymes in malignant and benign tumors of human lungs.
pubmed:affiliation
Clinical and Biochemical Laboratory, Department of Thoracic Surgery, A. V. Vishnevskii Institute of Surgery, Russian Academy of Medical Sciences.