Linked Life Data

12446726

Source:http://linkedlifedata.com/resource/pubmed/id/12446726

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-2-3
pubmed:abstractText
Terminally differentiated cardiac myocytes adapt to mechanical and neurohumoral stress via morphological changes of individual cells accompanied by reactivation of fetal pattern of gene expression. Endothelin-1, a powerful paracrine mediator of myocyte growth, induces similar changes in cultured cardiac myocytes as those seen in hypertrophied heart in vivo. By using rat B-type natriuretic peptide promoter, we identified a novel ETS binding sequence, on which nuclear protein binding is activated in endothelin-1-treated cultured cardiac myocytes. This sequence binds ETS-like gene-1 transcription factor and mediates endothelin-1-specific activation of transcription, but not responses to increased calcium signaling via l-type calcium channels, angiotensin II treatment, or mechanical stretch of myocytes. Interestingly, endothelin-1 activated signaling converges via p38 mitogen-activated protein kinase-dependent mechanism on ETS binding site, whereas this element inhibits extracellular signal-regulated kinase activated transcription. In conclusion, given the fundamental role of the interaction of mitogen-activated protein kinases and ETS factors in regulation of eukaryotic cell differentiation, growth, and oncogenesis, these results provide the unique evidence of a endothelin-1- and mitogen-activated protein kinase-regulated ETS factor pathway for cardiac myocytes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
278
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3969-75
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:12446726-Animals, pubmed-meshheading:12446726-Atrial Natriuretic Factor, pubmed-meshheading:12446726-Base Sequence, pubmed-meshheading:12446726-Cell Nucleus, pubmed-meshheading:12446726-Cells, Cultured, pubmed-meshheading:12446726-DNA Primers, pubmed-meshheading:12446726-Electrophoretic Mobility Shift Assay, pubmed-meshheading:12446726-Endothelin-1, pubmed-meshheading:12446726-Gene Expression Regulation, pubmed-meshheading:12446726-Mitogen-Activated Protein Kinases, pubmed-meshheading:12446726-Myocardium, pubmed-meshheading:12446726-Natriuretic Peptide, Brain, pubmed-meshheading:12446726-Nuclear Proteins, pubmed-meshheading:12446726-Promoter Regions, Genetic, pubmed-meshheading:12446726-Rats, pubmed-meshheading:12446726-Rats, Sprague-Dawley, pubmed-meshheading:12446726-Transcription, Genetic, pubmed-meshheading:12446726-p38 Mitogen-Activated Protein Kinases
pubmed:year
2003
pubmed:articleTitle
Endothelin-1-specific activation of B-type natriuretic peptide gene via p38 mitogen-activated protein kinase and nuclear ETS factors.
pubmed:affiliation
Department of Pharmacology and Toxicology, Biocenter Oulu, University of Oulu, P. O. Box 5000, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't