12445427

Source:http://linkedlifedata.com/resource/pubmed/id/12445427

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021734, umls-concept:C0030705, umls-concept:C0205195, umls-concept:C0209368, umls-concept:C0524910
pubmed:dateCreated	2002-11-26
pubmed:abstractText	Since ribavirin was able to improve the antiviral efficacy of interferon alfa in patients with chronic hepatitis C, several other adjuncts have been studied. It has been shown that mycophenolate mofetil (MMF) is a more potent inhibitor of the inosine 5'-monophosphate-dehydrogenase (IMPDH) than ribavirin. The present study is a pilot study evaluating the efficacy and safety of combination therapy with interferon alfa-2a and MMF in interferon alfa nonresponder patients.
pubmed:language	eng
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents, http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha, http://linkedlifedata.com/resource/pubmed/chemical/Interferons, http://linkedlifedata.com/resource/pubmed/chemical/Mycophenolic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/interferon alfa-2a, http://linkedlifedata.com/resource/pubmed/chemical/mycophenolate mofetil
pubmed:status	MEDLINE
pubmed:author	pubmed-author:BergThomasT, pubmed-author:CornbergMarkusM, pubmed-author:FalkenbergChristianC, pubmed-author:HinrichsenHolgerH, pubmed-author:MannsMichael PMP, pubmed-author:NaumannUtaU, pubmed-author:TeuberGerlindeG, pubmed-author:ZeuzemStefanS
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	843-7
pubmed:dateRevised	2011-11-17
pubmed:articleTitle	Mycophenolate mofetil in combination with recombinant interferon alfa-2a in interferon-nonresponder patients with chronic hepatitis C.
pubmed:affiliation	Department of Gastroenterology, Hepatology, and Endocrinology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D-30625 Hannover, Germany.