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pubmed:abstractText |
Four new analogues of Targretin where the carboxylic acid function was replaced by an N,N-dimethyl-S-aryl carbamate or N,N-dimethyl-O-arylthiocarbamate function, were synthesized. Compounds 5, 6 and 7 have shown to be more potent than the parent compound to induce apoptosis of HL-60 cells.
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pubmed:affiliation |
Laboratoire de Chimie Biomoléculaire, UMR 5032, Université Montpellier II - CNRS - Laboratoires Mayoly Spindler, ENSCM, 8 Rue de l'Ecole Normale, 34296 Montpellier Cedex, France.
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