Linked Life Data

12443596

Source:http://linkedlifedata.com/resource/pubmed/id/12443596

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2002-11-21
pubmed:abstractText
Hand function depends on tendon integrity, but in rheumatoid arthritis tenosynovitis can result in tendon adhesions and rupture. Cytokine inhibitors have proved effective in rheumatoid joint disease; however, their effect on the tenosynovium is not well understood. We investigated the ability of inhibitors of tumour necrosis factor alpha and interleukin 1 to reduce production of collagenolytic matrix metalloproteinases 1 and 13 in tenosynovial tissue obtained from patients with rheumatoid arthritis. Our data show that cytokine blockade can reduce collagenase concentrations in tenosynovial tissue, suggesting cytokine inhibitors could be effective in reduction of tendon damage.
pubmed:language
eng
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:author
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1565-6
pubmed:dateRevised
2006-11-15
pubmed:articleTitle
Treatment of rheumatoid tenosynovitis with cytokine inhibitors.
pubmed:affiliation
Department of Musculoskeletal Surgery, Imperial College School of Medicine, Charing Cross Hospital Campus, Arthritis Research Campaign Building, London, UK. AJainUK@aol.com