Source:http://linkedlifedata.com/resource/pubmed/id/12441807
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2002-11-20
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| pubmed:abstractText |
We have cloned and sequenced the chimpanzee (Pan troglodytes) cyclin T1 cDNA and performed functional HIV-1 Tat trans-activation studies. A unique codon deletion leading to a deleted asparagine residue in the N-terminal region of the first cyclin domain was discovered. This mutation does not significantly change the trans-activation of HIV-1, suggesting that Tat-Cyclin T1 mediated transcription is not a major barrier to HIV replication in the chimpanzee.
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| pubmed:language |
eng
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| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:author | |
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2335-7
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| pubmed:dateRevised |
2008-11-21
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| pubmed:articleTitle |
A unique amino acid deletion in the chimpanzee Cyclin T1 does not affect Tat trans-activation of HIV.
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| pubmed:affiliation |
Swedish Institute for Infectious Disease Control and Microbiology and Tumorbiology Center, Stockholm, Sweden.
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