| pubmed-article:12438388 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:12438388 | lifeskim:mentions | umls-concept:C0383327 | lld:lifeskim |
| pubmed-article:12438388 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:12438388 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:12438388 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:12438388 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:12438388 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12438388 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12438388 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12438388 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12438388 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:12438388 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:12438388 | pubmed:dateCreated | 2002-11-19 | lld:pubmed |
| pubmed-article:12438388 | pubmed:abstractText | Oral candidiasis is a collective name for a group of disorders caused by the dimorphic fungus Candida albicans. Host defenses against C. albicans essentially fall into two categories: specific immune mechanisms and local oral mucosal epithelial cell defenses. Since oral epithelial cells secrete a variety of cytokines and chemokines in response to oral microorganisms and since C. albicans is closely associated with oral epithelial cells as a commensal organism, we wanted to determine whether interleukin-18 (IL-18) and gamma interferon (IFN-gamma) were produced by oral epithelial cells in response to C. albicans infection and lipopolysaccharide (LPS) stimulation. Our results showed that IL-18 mRNA and protein were constitutively expressed by oral epithelial cells and were down-regulated by Candida infections but increased following LPS stimulation. Both C. albicans and LPS significantly decreased pro-IL-18 (24 kDa) levels and increased active IL-18 (18 kDa) levels. This effect was IL-1beta-converting-enzyme dependent. The increase in active IL-18 protein levels promoted the production of IFN-gamma by infected cells. No effect was obtained with LPS. Although produced only at an early stage, secreted IFN-gamma seemed to be a preferential response by oral epithelial cells to C. albicans growth. These results provide additional evidence for the contribution of oral epithelial cells to local (direct contact) and systemic (IL-18 and IFN-gamma production) defense against exogenous stimulation such as C. albicans infection or LPS stimulation. | lld:pubmed |
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| pubmed-article:12438388 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12438388 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12438388 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12438388 | pubmed:author | pubmed-author:ChakirJamilaJ | lld:pubmed |
| pubmed-article:12438388 | pubmed:author | pubmed-author:RouabhiaMahmo... | lld:pubmed |
| pubmed-article:12438388 | pubmed:author | pubmed-author:RossGeneviève... | lld:pubmed |
| pubmed-article:12438388 | pubmed:author | pubmed-author:PagéNathalieN | lld:pubmed |
| pubmed-article:12438388 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12438388 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12438388 | pubmed:pagination | 7073-80 | lld:pubmed |
| pubmed-article:12438388 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12438388 | pubmed:articleTitle | Interleukin-18 and gamma interferon production by oral epithelial cells in response to exposure to Candida albicans or lipopolysaccharide stimulation. | lld:pubmed |
| pubmed-article:12438388 | pubmed:affiliation | Faculté de médecine dentaire. GREB, Université Laval, Québec G1K 7P4, Canada. Mahmoud.rouabhia@fmd.ulaval.ca | lld:pubmed |
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