|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006837,
umls-concept:C0014597,
umls-concept:C0021745,
umls-concept:C0023810,
umls-concept:C0033268,
umls-concept:C0332157,
umls-concept:C0383327,
umls-concept:C0442027,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1948023,
umls-concept:C2911692
|
|
pubmed:dateCreated |
2002-11-19
|
|
pubmed:abstractText |
Oral candidiasis is a collective name for a group of disorders caused by the dimorphic fungus Candida albicans. Host defenses against C. albicans essentially fall into two categories: specific immune mechanisms and local oral mucosal epithelial cell defenses. Since oral epithelial cells secrete a variety of cytokines and chemokines in response to oral microorganisms and since C. albicans is closely associated with oral epithelial cells as a commensal organism, we wanted to determine whether interleukin-18 (IL-18) and gamma interferon (IFN-gamma) were produced by oral epithelial cells in response to C. albicans infection and lipopolysaccharide (LPS) stimulation. Our results showed that IL-18 mRNA and protein were constitutively expressed by oral epithelial cells and were down-regulated by Candida infections but increased following LPS stimulation. Both C. albicans and LPS significantly decreased pro-IL-18 (24 kDa) levels and increased active IL-18 (18 kDa) levels. This effect was IL-1beta-converting-enzyme dependent. The increase in active IL-18 protein levels promoted the production of IFN-gamma by infected cells. No effect was obtained with LPS. Although produced only at an early stage, secreted IFN-gamma seemed to be a preferential response by oral epithelial cells to C. albicans growth. These results provide additional evidence for the contribution of oral epithelial cells to local (direct contact) and systemic (IL-18 and IFN-gamma production) defense against exogenous stimulation such as C. albicans infection or LPS stimulation.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-10225924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-10229854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-10384110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-10458979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-10496873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-10759414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-10856773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-11008115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-11029688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-11132762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-11204167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-11244043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-11340532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-11465697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-11468102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-11544464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-11590489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-11714826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-11766885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-11805151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-11989714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-2576159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-3093587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-3319419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-6409884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-6996654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-7477296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-7607390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-7936590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-8051426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-8335982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-8390485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-8447935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-8628393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-8999548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-9121587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-9184009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-9200466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-9317010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-9325078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-9453626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-9504059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-9529101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-9529155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-9759875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12438388-9893178
|
|
pubmed:language |
eng
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:author |
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
7073-80
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:articleTitle |
Interleukin-18 and gamma interferon production by oral epithelial cells in response to exposure to Candida albicans or lipopolysaccharide stimulation.
|
|
pubmed:affiliation |
Faculté de médecine dentaire. GREB, Université Laval, Québec G1K 7P4, Canada. Mahmoud.rouabhia@fmd.ulaval.ca
|
