Source:http://linkedlifedata.com/resource/pubmed/id/12437650
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2002-11-19
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| pubmed:abstractText |
We report a patient with hypereosinophilic syndrome (HES), which, 8 years later, transformed into granulocytic sarcoma in the brain and, subsequently, into acute myelocytic leukaemia. Repeated chromosome analyses showed a normal karyotype, until the time of leukaemic transformation when trisomy 8 was confirmed in cells from the bone marrow and cerebrospinal fluid. The combined techniques of May-Grunwald-Giemsa staining and fluorescence in situ hybridization identified trisomy 8 not only in blasts and eosinophils but also in neutrophils and erythroblasts. Our observation suggests that HES is a multilineage myeloproliferative disorder involving precursors of at least the eosinophil, neutrophil and erythroid lineages.
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| pubmed:language |
eng
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| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:author |
pubmed-author:AshibaAtsukoA,
pubmed-author:FujiiNobuharuN,
pubmed-author:FukudaShunnichiS,
pubmed-author:HaradaMineM,
pubmed-author:IkedaKazumaK,
pubmed-author:IshimaruFumihikoF,
pubmed-author:KobayashiYoshimiY,
pubmed-author:KojimaKensukeK,
pubmed-author:MiuraIkuoI,
pubmed-author:NiiyaKenjiK,
pubmed-author:ShinagawaKatsujiK,
pubmed-author:TakahashiNaotoN,
pubmed-author:TakenakaKatsutoK,
pubmed-author:TanimotoMitsuneM
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
716-9
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| pubmed:dateRevised |
2007-11-15
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| pubmed:articleTitle |
Multilineage involvement in hypereosinophilic syndrome terminating in granulocytic sarcoma and leukaemic transformation with trisomy 8.
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| pubmed:affiliation |
Department of Internal Medicine (II), Okayama University Medical School, Okayama, Japan. nfujii@md.okayama-u.ac.jp
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