Erythropoietin (EPO) and its receptor play a major role in embryonic brain, are weakly expressed in normal postnatal/adult brain and up-regulated upon metabolic stress. EPO protects neurons from hypoxic/ ischemic injury. The objective of this trial is to study the safety and efficacy of recombinant human EPO (rhEPO) for treatment of ischemic stroke in man.
Max-Planck-Institute for Experimental Medicine, Departments of Neurology and Psychiatry, Georg-August-University, Goettingen, Germany. ehrenreich@em.mpg.de