Source:http://linkedlifedata.com/resource/pubmed/id/12432502
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| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2002-11-14
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| pubmed:abstractText |
Interleukin 13 (IL-13) has been demonstrated to have a crucial role in animal models of allergy and asthma. In human case-control genetic-association studies, the Arg130Gln polymorphism has been associated with elevated total serum IgE and an asthma diagnosis in atopic and nonatopic individuals (Graves et al. [2000] J. Allergy Clin. Immunol. 105:506-513; Heinzmann et al. [2000] Hum. Mol. Genet. 9:549-559). To apply family-based association methods, we obtained DNA samples from 685 asthmatic children from 640 sibships and their parents in the Childhood Asthma Management Program (CAMP). Six hundred and sixty-six asthmatic children had complete phenotypic information and were used for this analysis. We performed quantitative association analysis using the transmission disequilibrium test (TDT) on 22 individual phenotypes and 5 grouped phenotypes relating to allergy, airway responsiveness, pulmonary function, bronchodilator responsiveness, and asthma severity, using genotypes at the Arg130Gln polymorphism of the IL-13 gene. A positive association was obtained between Arg130Gln and a grouped phenotype of allergy (consisting of the individual phenotypes of eosinophils, IgE, and positive skin tests), using FBAT-GEE, a multivariate extension of the family-based association test (Lange et al. [2002] Biostatistics 1:1-15). The three phenotypes were then evaluated individually and revealed a significant association between total eosinophil count and the Arg130Gln locus; there was a trend for association between total IgE and the Arg130Gln polymorphism. The Arg130Gln polymorphism is associated with an elevated eosinophil count as well as with a grouped allergy phenotype, in children with mild to moderate asthma. No evidence for association was found between Arg130Gln and airway responsiveness, asthma diagnosis, or asthma severity.
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| pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/1 R01 HL66386-01,
http://linkedlifedata.com/resource/pubmed/grant/1 U01 HL66795-01,
http://linkedlifedata.com/resource/pubmed/grant/2 T32 HL07427-21,
http://linkedlifedata.com/resource/pubmed/grant/MH 59532,
http://linkedlifedata.com/resource/pubmed/grant/N01-HR-16044,
http://linkedlifedata.com/resource/pubmed/grant/N01-HR-16045,
http://linkedlifedata.com/resource/pubmed/grant/N01-HR-16046,
http://linkedlifedata.com/resource/pubmed/grant/N01-HR-16047,
http://linkedlifedata.com/resource/pubmed/grant/N01-HR-16048,
http://linkedlifedata.com/resource/pubmed/grant/N01-HR-16049,
http://linkedlifedata.com/resource/pubmed/grant/N01-HR-16050,
http://linkedlifedata.com/resource/pubmed/grant/N01-HR-16051,
http://linkedlifedata.com/resource/pubmed/grant/N01-HR-16052
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| pubmed:language |
eng
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| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2002 Wiley-Liss, Inc.
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
335-48
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| pubmed:dateRevised |
2007-11-14
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| pubmed:articleTitle |
Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program.
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| pubmed:affiliation |
Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
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